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Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI

Recruitingn/aAges 15 Years - 65 YearsAllBenha University
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to compare the diagnostic accuracy of Phase-Sensitive Inversion Recovery (PSIR) MRI versus conventional T2-weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) sequences in detecting early brain lesions in patients with Multiple Sclerosis (MS). The study will include male and female participants aged 15-65 years diagnosed with MS per the 2017 McDonald criteria. This study hypothesizes that: * PSIR MRI will detect a significantly higher number of cortical lesions (intracortical, leukocortical, and juxtacortical) compared to conventional T2W and FLAIR sequences in MS patients (p \< 0.05). * Lesions identified exclusively by PSIR will correlate more strongly with clinical measures (EDSS disability scores and SDMT cognitive performance) than those detected by T2W/FLAIR alone, suggesting PSIR's superior sensitivity to clinically relevant pat

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age between 15-65 years. * Both sexes. * Patients with MS according to McDonald Criterion Exclusion Criteria: * Age less than 15 years old. * Patients with stroke or previous intracranial hemorrhage. * Contraindications to MRI scans. * MS mimics.
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What it tests

  • Not listed
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Where

3 sites
Banha University Hospitals
Banhฤ, Egypt
El Mounira Multiple Sclerosis Unit
Cairo, Egypt
Naser Institute MS Unit
Cairo, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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