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Neural Mechanism of Cerebrocardiac Syndrome Following Traumatic Brain Injury

Recruitingn/aAges 18 Years - 80 YearsAllShanghai 6th People's Hospital
NCT06958406 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cerebrocardiac syndrome (CCS), including myocardial injury, arrhythmia or heart failure is one of serious complications of traumatic brain injury (TBI), mostly occurs within seven days after TBI, which directly aggravates the brain damage and affects the prognosis of TBI patients. Accumulative evidences suggest that autonomic nervous system disorder is a key initiation point for CCS, but how TBI affects the specific action patterns is not yet clear. Therefore, elucidating the neural mechanisms of TBI-induced CCS, maintaining the central sympathetic-parasympathetic balance through novel interventions such as noninvasive brain stimulation, may fundamentally block the downstream peripheral mechanism, thus achieving effective prevention and treatment for CCS. Based on the current emerging research in brain connectomics and lesion-symptom mapping, we speculate that cerebral contusions can cau

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with isolated closed head trauma * Age 18-80 years old * Admitted to hospital within 24 hours of injury * Mild or moderate TBI (Glasgow Coma Scale score of 9-15) * Signed consent form Exclusion Criteria: * Severe TBI (Glasgow Coma Scale score of 3-8) * A history of stroke, TBI, intracranial tumor or surgery in the past 1 year * A history of coronary heart disease, structural heart disease and other primary heart diseases or suspected cardiac symptoms prior to injury * Causes of abnormal cardiac biomarkers such as renal insufficiency, severe anemia, sepsis, cardiotoxic drugs and so on * Not suitable for MRI examinations, such as pregnant women and those with metal implants in the body * Undergo surgery prior to MRI examinations or cardiac testing
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What it tests

  • Not listed
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Where

2 sites
Shanghai 6th People's Hospital
Shanghai, China
Shanghai Sixth People's Hospital
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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