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Tuberculosis in Rural and Malnourished Populations

RecruitingNAAges any - anyAllUniversity of Virginia
NCT06971952 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Tuberculosis (TB) remains a large public health threat in Tanzania with an estimated incidence of 195 per 100,000 people in 2022 and 36% of cases going undiagnosed. Nutritional and financial barriers combine to compound the burden of TB in Tanzania and many other high burden countries. Objectives: In this study, we aim to evaluate the effect and cost-effectiveness of conditional cash transfer added to the current facility-based approach to improve TB screening among household contacts (HHCs) of index people diagnosed with TB disease (PWTB) in rural Tanzania; and characterize the prevalence of undernutrition among HHCs of index PWTB and quantify the effect of undernutrition severity on the progression to active TB disease. Methods: In this prospective, interventional cohort study we plan to enroll 360 PWTB and their households within 2 months of TB treatment initiation. The

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📋 Eligibility rules (as published)
Inclusion Criteria: * Index person/people diagnosed with drug sensitive pulmonary tuberculosis disease (PWTB) and starting TB treatment within 2 months of enrollment, of any age. * Index PWTB are eligible if they reside within the catchment area of Haydom Lutheran Hospital (HLH), and * Index PWTB intend to receive TB care at a participating study site. * Index PWTB (or their parent or guardian if index PWTB are \<18 years) and head of household (if different from index PWTB) are able and willing to provide informed consent. Exclusion Criteria: * Inability to provide informed consent, or assent when applicable. * Residing or receiving TB care outside of the catchment area of study sites * Prior completion of TB screening procedures for all household members.
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What it tests

  • Conditional Cash Transfer Incentive for Household Contact Screening
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Where

1 site
Haydom Lutheran Hospital
Haydom, Tanzania
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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