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Effects of Blood Flow Restriction Training on Muscle Strength and Physical Function for Stroke-Related Sarcopenia

RecruitingNAAges 50 Years - anyAllThe Hong Kong Polytechnic University
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In plain words

What the trial is, and whether it could suit you

Effects of Blood Flow Restriction Walking on Muscle Strength and Physical Function in Chronic Stroke Patients with Sarcopenia: A Randomized, Sham-Controlled Trial Primary Objective: To evaluate the effects of BFR walking on muscle strength and physical function in chronic stroke patients with sarcopenia, compared to sham-BFR walking. Secondary Objective: (1) To explore the potential impact of BFR walking on muscle mass and vascular function in chronic stroke patients with sarcopenia. (2) To assess the influence of BFR walking on quality of life in chronic stroke patients with sarcopenia.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosed with chronic stroke (≥6 months post-stroke) * Sarcopenia will be diagnosed using the Asian Working Group for Sarcopenia (AWGS) 2025 criteria, defined as the concurrent presence of low muscle strength and low appendicular skeletal muscle mass. Muscle strength will be assessed using handgrip strength measured on the non-paretic side. Low muscle strength will be defined as handgrip strength \<28 kg for men and \<18 kg for women aged ≥65 years, and \<34 kg for men and \<20 kg for women aged 50-64 years. Appendicular skeletal muscle mass will be measured using bioelectrical impedance analysis, and the appendicular skeletal muscle mass index will be calculated as appendicular skeletal muscle mass divided by height squared. Low muscle mass will be defined as an appendicular skeletal muscle mass index \<7.0 kg/m² for men and \<5.7 kg/m² for women aged ≥65 years, and \<7.6 kg/m² for men and \<5.7 kg/m² for women aged 50-64 years. Exclusion Criteria: * Stroke occurred within the past 6 months * Resting systolic blood pressure \> 200 mmHg * Resting diastolic blood pressure \> 100 mmHg * Presence of implanted electronic or metallic devices that interfere with blood flow restriction cuffs * Contraindication to bioelectrical impedance analysis (e.g., pacemaker, ICD)
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What it tests

  • Blood Flow Restriction (BFR) Walking
  • Sham Blood Flow Restriction (Sham-BFR) Walking
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Where

2 sites
Hong Kong Polytechnic University
Hung Hom, Hong Kong
Hong Kong Polytechnic University
Hung Hom, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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