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Sodium in the Skin and Atopic Dermatitis

Recruitingn/aAges 50 Years - anyAllUniversity of California, San Francisco
NCT06998446 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above. The study is designed to test whether diet and skin barrier function are associated with skin sodium concentration and whether skin sodium concentration is linked to atopic dermatitis and immune profiles over time. Participants will be asked to complete questionnaires, provide bio samples, and undergo non-contrast sodium MRI at 2-3 time points over 3-24 months.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Ages 50 years and above * Willing to undergo non-contrast MRI (e.g., no contraindications to MRI, such as cardiac pacemakers, non-compatible intracranial vascular clips or pregnancy). Exclusion Criteria: * History of autoimmune disease. * Cardiac events in the last six months. * Impaired function of the liver or kidneys (glomerular filtration rate \<60ml/min). * Current use of medications that influence sodium excretion (e.g. thiazide diuretics, SGLT2 inhibitors and spironolactone), and/or chemotherapy or antibiotic treatment. * Currently receiving phototherapy or taking systemic medications for atopic dermatitis including cyclosporine, methotrexate, or other broad immunosuppressive medications. (Patients on dupilumab will not be excluded if they have been on dupilumab for at least two months and still meet the criteria for severe disease.)
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What it tests

  • Not listed
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Where

2 sites
San Francisco VA Medical Center
San Francisco, United States
UCSF Mt Zion Campus
San Francisco, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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