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Screening for Early Diagnosis of Nose Cancer

RecruitingNAAges 35 Years - 60 YearsAllNational University Hospital, Singapore
NCT07019870 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate the effectiveness of screening in identifying nasopharyngeal cancer (NPC), and evaluate the performance of Epstein-Barr virus (EBV) biomarkers in a community screening setting in Singapore. Participants will assessed for their risk of NPC using EBV Early Antigen (EA) IgA serology and cell-free plasma EBV DNA. If the initial plasma EBV DNA test is positive, a repeat blood sample will be taken and tested. Saliva will also be collected for evaluation of EBV risk strains, but not used for risk evaluation. 1. High risk individuals are determined by: * a positive EBV EA IgA serology test, and/or * two consecutive positive plasma EBV DNA tests High risk individuals will undergo evaluation in the outpatient Otolaryngology clinic. The evaluation includes a head and neck examination, nasoendoscopy and nasopharyngeal biopsy. Clinical data

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📋 Eligibility rules (as published)
Inclusion Criteria: * Chinese, Malay, and mixed ethnicities * individuals not diagnosed with NPC * individuals with family history of NPC Exclusion Criteria: * younger than 35, older than 60 * individuals already diagnosed with NPC * pregnant women
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What it tests

  • EBV biomarker testing
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Where

2 sites
National University Hospital
Singapore, Singapore
National University Polyclinics
Singapore, Singapore
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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