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Stress Trajectories and Anhedonia in Adolescence Research Study

RecruitingNAAges 13 Years - 15 YearsAllUniversity of North Carolina, Chapel Hill
NCT07040449 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) in adolescence. The goal of this project is to see if it is possible to combine these biological measures to describe different patterns of activity in the brain and body that adolescents may have in response to stress. The main question this study aims to answer is whether different patterns of activity in the brain and body are related to whether adolescents develop anhedonia and how high or low levels of anhedonia are over time. This study will enroll 192 adolescents who are between 13 and 15 years. Adolescents will complete tasks three times: at the beginning of the study, 10 months after that, and then 10 months after that. In total, they will be part of the study for 20 months. At each time, adolescents will complete survey

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 13-15 years old at study entry * Ability to understand and sign an assent form * Meets study hearing and vision requirements Exclusion Criteria: * Current use of medications that would interfere with cardiovascular or endocrine assessments * Metal in the body or other MRI exclusion * Medical condition or injury that could confound brain imaging evaluations or interfere with cardiovascular or endocrine assessments * Impaired intellectual functioning * Diagnosed with a neurodevelopmental disability
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What it tests

  • Montreal Imaging Stress Task
  • Trier Social Stress Test for Children
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Where

1 site
University of North Carolina at Chapel Hill
Chapel Hill, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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