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Mechanism of Gamma Oscillation Synchronization in the Prefrontal-hippocampal Circuit for Memory Dysfunction in Patients With White Matter Lesions of Cerebral Small Vessel Disease

Recruitingn/aAges 55 Years - 75 YearsAllXuanwu Hospital, Beijing
NCT07042633 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The mechanism underlying memory impairment caused by white matter lesions of cerebral small vessel disease is still unclear. The disrupted synchronization of gamma oscillations in the prefrontal-hippocampal circuit is a potential key mechanism. Our study has demonstrated that white matter lesions lead to demyelination of the connection tracts between the prefrontal lobe and hippocampus, which is closely related to memory dysfunction. However, further studies are required to explore if these microstructural changes in white matter tracts influence memory function by affecting gamma oscillations. Thus, this project will use the previously established episodic memory task and event-related potential to determine the changes in gamma oscillations in the prefrontal-hippocampal circuit and the effects on memory encoding and retrieval. Combining multimodal imaging, we will explore the mediating

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📋 Eligibility rules (as published)
Inclusion Criteria: * \- Individuals with cerebral small vessel disease, normal cognition or mild cognitive impairment subjects; * Participants with complete demographic data, neuropsychiatric scale assessments, imaging data, and EEG data. Exclusion Criteria: * Severe aphasia, physical disability, or other conditions preventing completion of neuropsychological assessments; * History of cerebrovascular stroke with documented neurological deficits during onset and corresponding lesions on neuroimaging; * Neurological disorders that may cause cognitive impairment, including alcohol abuse, drug addiction, traumatic brain injury, epilepsy, encephalitis, or normal-pressure hydrocephalus; * Systemic diseases potentially contributing to mild cognitive impairment (e.g., hepatic/renal insufficiency, endocrine disorders, vitamin deficiencies); * Current diagnosis of major depressive disorder or psychiatric disorders.
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What it tests

  • Not listed
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Where

1 site
Xuanwu Hospital Capital Medical University
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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