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Effects of Frontopolar TMS in Alcohol Craving

RecruitingNAAges 18 Years - 65 YearsAllGoethe University
NCT07064590 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this interventional study is to learn if continuous theta burst stimulation (cTBS) applied over the left frontopolar cortex can reduce psychological, physiological, and neurobiological markers of alcohol craving in patients with alcohol dependence (AD). The main questions it aims to answer are: * Does cTBS over the left frontopolar cortex reduce psychological and physiological measures of alcohol craving in individuals with AD? * Are baseline structural and functional brain connectivity patterns associated with individual differences in cTBS-induced changes in craving? The participants will: * Receive cTBS over the left frontopolar cortex using an accelerated protocol comprising 15 TMS-sessions on five consecutive days * Undergo psychological and physiological assessments of alcohol craving before and after the TMS intervention * Complete magnetic resonance imaging (MRI)

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📋 Eligibility rules (as published)
Inclusion Criteria: * adults aged 18-65 * ICD-10 diagnosis of alcohol dependence * Ability to give consent * Sinus rhythm in ECG Exclusion Criteria: * Current psychotic symptoms in patients with psychotic disorders (F20, F23, F10.5) * Contraindication against TMS or MRI * Severe neurological disorders such as epilepsy, stroke, neuroinflammatory disorders (e.g., multiple sclerosis). A history of seizures only in the context of alcohol withdrawal does not represent a contraindication, unless the seizure happened in the last 3 weeks before study inclusion. * Acute withdrawal symptoms (CIWA-Ar \> 5)
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What it tests

  • Transcranial Magnetic Stimulation (TMS)
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Where

2 sites
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie Universitätsklinikum Frankfurt, Goethe-Universität
Frankfurt am Main, Germany
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie Universitätsklinikum Frankfurt, Goethe-Universität
Frankfurt am Main, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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