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โ† Trials
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Recovery With Exogenous Ketones and Antipsychotics

RecruitingNAAges 18 Years - 35 YearsAllUniversitรฉ de Sherbrooke
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In plain words

What the trial is, and whether it could suit you

The RECAP project will evaluate the clinical and metabolic effects of adding exogenous ketones to antipsychotic (AP) treatment in young adults with a first episode of psychosis (FEP). FEP requires early intervention to limit relapse, chronic symptoms, cognitive decline, and reduced life expectancy. Symptoms include positive (hallucinations, delusions), negative (amotivation, anhedonia), cognitive (attention, working memory), and mood disturbances. Standard care combines second- or third-generation APs with psychosocial interventions. However, many patients have persistent symptoms despite optimal treatment. Psychosis is linked to increased cardiovascular and obesity risk. APs can cause insulin resistance, type 2 diabetes, and dyslipidemia, but some metabolic abnormalities-both systemic and cerebral-may precede AP use, suggesting an intrinsic metabolic dysfunction. Brain energy metaboli

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Referred or self-referred to the PEP Clinic of the Estrie region, either as an outpatient or inpatient. * Currently receiving a second- or third-generation antipsychotic at a stable dose for at least 4 weeks. * Able to read and communicate in French or English. * Capable of understanding and signing the informed consent form. Exclusion Criteria: * Pregnancy, childbirth within the past 6 months, or breastfeeding. * any use of MCT oil, ketone salts, or a ketogenic diet within the past year. * Previous diagnosis of type I or type II diabetes. * Uncontrolled acute suicidal ideation at the time of inclusion in the PEP clinic. * Other conditions that may interfere with participation, as determined by the qualified physician. * Pancreatitis (inflammation of the pancreas) or liver failure. * Metabolic condition affecting fat metabolism or inherited carnitine deficiency and its related enzymes. * Porphyria. * Pyruvate kinase deficiency. * Neurodevelopmental disorder of unknown etiology or rare genetic disease.
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What it tests

  • Medium chain triglyceride oil
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Where

1 site
Hotel-Dieu CIUSSS de l'Estrie-CHUS
Sherbrooke, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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