💬In plain words
What the trial is, and whether it could suit you
The CHARM network will be established through three primary institutions-Beth Israel Deaconess Medical Center (BIDMC), the University of California San Diego (UCSD), and the University of Washington (UW)-along with their subcontracting institutions. At UCSD and partner sites, the CHARM network will be implemented via the PREVENT project. All PREVENT participants will be consented in to Component A0 (Community Testing) and a subset of A0 participants will be invited to participate and will be consented into the other components: Component A (Ongoing Testing); Component A Sub-study (Immunology); Component B (Household Transmission).
Component A0 participants (Community testing) will be members of the community who are interested in accessing testing for respiratory infections and will be asked to provide limited information that will then be used for screening for study Components A and/o
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Community Testing Component:
Inclusion:
\- All community members are able to participate in the community testing component.
Exclusion:
\- There is no exclusion criteria and participants will not be excluded based on pregnancy status or age.
For Component A:
Inclusion:
* All ages
* AND Lives in service area of a recruitment center (i.e., within range of courier pick up)
* AND Plans to remain living in a recruitment area for the next 2 years.
Exclusion:
* Inability to communicate in a language in which consent forms, materials, etc. are available
* OR Incarcerated
* OR Living in a congregate setting (e.g., assisted living, nursing home, university dormitories with shared bathroom and communal eating facilities)
* OR Unable/unwilling to participate in planned data and specimen collections
* OR Unable to comply with study procedures, as determined by study investigators
* OR Participation in clinical trials of investigational agents for respiratory viral infections during the three months prior to enrollment and for the duration of the study.
For Component B:
Inclusion:
Index case:
* Detection of priority respiratory pathogen via laboratory or point-of-care test on the day of eligibility screening or in the previous 5 days, AND
* Lives in service area of a recruitment center (i.e., within range of courier pick up), AND
* Lives in a household with ≥1 other person and plans to remain in the household for at least the duration of specimen collection (i.e., 14 days), AND
* Has not been hospitalized since the date of symptom onset.
Household contacts:
* Routinely sleep in the same household as index case and slept in household ≥1 night in the 7 days before index case symptom onset, AND
* Plan to remain in the household for at least the duration of specimen collection (i.e., 14 days).
Household:
* There is ≥1 non-ill household member (i.e., asymptomatic and has not tested positive for the virus of the index case) on the day of eligibility screening or in the previous 5 days,
* AND all symptomatic persons in the household had a symptom or diagnosis onset date on the day of eligibility screening or in the previous 5 days.
Exclusion:
Index case:
* Lives in a congregate setting (e.g., assisted living, nursing home, university dormitories with shared bathroom and communal eating facilities)
* Meet any A1 exclusion criteria
Household contacts:
* Has been hospitalized any time since date of primary case symptom onset
* Meets any A1 exclusion criteria
Household:
* The enrollment visit occurs \>6 days after the first symptom onset of primary case
* The primary case in the household is not enrolled
* The primary case has been hospitalized any time after the date of symptom onset
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