The Effect of Oral Clostridium Butyricum on the Recurrence After Colonoscopic Resection of Colorectal Adenoma

Inclusion Criteria: * Age between 18 and 75 years * No restriction on sex * Boston Bowel Preparation Score (BBPS) ≥ 7 prior to endoscopic procedure * Completed endoscopic resection of colorectal adenomas (including cold snare polypectomy, ESD, EMR, etc.) with no residual adenomas or polyps observed endoscopically * Histologically confirmed adenomas (including tubular, villous, or tubulovillous types) without malignant transformation * Able to take oral medication * Signed informed consent Exclusion Criteria: * Use of probiotics, prebiotics, synbiotics, or antibiotics within 2 weeks prior to enrollment * Presence of psychiatric disorders or other conditions preventing compliance with the intervention * Dysfunction of vital organs (liver, kidney, heart, etc.) deemed unsuitable for clinical study participation after evaluation * Participation in other clinical trials within 3 months prior to enrollment * History of gastrointestinal surgery (excluding endoscopic procedures) * History of inflammatory bowel disease * History of autoimmune diseases * Long-term use of aspirin (≥100 mg/day for over 3 months) or calcium supplements (≥1200 mg/day for over 3 months) * Pregnancy or breastfeeding * Previous treatment for colorectal adenomas (including endoscopic or surgical resection) * Familial adenomatous polyposis (FAP)