The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patients

Inclusion Criteria: 1. Age ≥18 years; 2. Receiving or eligible to receive exclusively gastric tube feeding; 3. Expected ICU stay ≥48 hours; 4. Receiving or anticipated to receive invasive mechanical ventilation within 48 hours after ICU admission. Exclusion Criteria: 1. The treating clinician considers participation in the study clinically contraindicated (e.g., change in feeding regimen, no possibility for placement of CGM on arms, not able to receive exclusive gastric tube feeding); 2. Death is deemed to be imminent or inevitable during admission, and the attending doctor, patient, or substitute decision-maker is not committed to active treatment; 3. Pregnancy; 4. Expected fasting for ≥12 hours during the study period, for example, due to medical procedures; 5. Readmission in last 14 days; 6. Patients with burn injuries; 7. Participating in another nutritional intervention study.