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Dual Energy CT - a Tool for Delineation of Tumor and Organs at Risk in Radiotherapy

Recruitingn/aAges 18 Years - anyAllAalborg University Hospital
NCT07185958 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The primary aim of this clinical study, 'Dual Energy CT - a tool for delineation of tumor and organs at risk in radiotherapy' (DART) is to evaluate whether dual-energy CT (DECT) is at least as effective as magnetic resonance imaging (MRI) in delineating both tumors and organs at risk (OARs) in patients referred for radiotherapy (RT). This primary aim will be explored in patient groups where the performance of DECT for RT has been described in the literature (but mostly based on signal-to-noise ratio and/or contrast-to-noise ratio), such as brain metastases (sub-cohort 'DART Brain') and head and neck cancer (sub-cohort 'DART H\&N'). Additionally, DART will explore diagnoses not yet studied in the literature, such as bone metastases (sub-cohort 'DART Bone'). If DECT could be demonstrated to achieve delineations for RT in both tumors and OARs that are equally accurate as those based on MRI,

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥18 years 2. ECOG performance status (PS) 0-2 3. Assessed to be able to complete the protocol scanning regime 4. Referred for RT 5. Signed informed consent 6. For patients with brain metastasis (cohort A): 1-5 brain metastases referred for ei-ther whole brain or stereotactic RT 7. For patients with bone metastasis (cohort B): Metastases in one or more regions of the vertebral column (C1-C7, Th1-12, L1-L5, Os Sacrum), without medullary involve-ment, referred for either palliative or stereotactic RT 8. For head and neck cancer patients (cohort C): A PET/CT scan must have been per-formed during the diagnostic evaluation for cancer 9. For lung cancer patients (cohort D): Only patients referred for palliative RT with a maximum of 10 fractions Exclusion Criteria: 1. Pregnancy 2. Previous RT in the same anatomical area now referred for RT 3. Previous surgery in the same anatomical area now referred for RT 4. Participation in conflicting protocols 5. If relevant for the protocol scanning regime: Allergic to contrast agent 6. If relevant for the protocol scanning regime: Contraindication to iodine-based contrast agent for CT (as determined by the physician) 7. If relevant for the protocol scanning regime: Contraindication to Gadolinium-based contrast agent for MRI (as determined by the physician) 8. If relevant for the protocol scanning regime: Contraindication for MRI (pacemaker, metal, non-MRI, compatible implants etc.) 9. Incapable of understanding the patient information
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What it tests

  • Dual-energy CT (DECT)
  • Iodine-based contrast agent
  • Magnetic Resonance Imaging (MRI)
  • Gadolinium-based contrast agent
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Where

3 sites
Aalborg University Hospital
Aalborg, Denmark
Copenhagen University Hospital Herlev and Gentofte
Herlev, Denmark
Odense University Hospital
Odense, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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