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Hippocampal and Frontoparietal Development and Inference

RecruitingNAAges 13 Years - 25 YearsAllUniversity of Texas at Austin
NCT07199907 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to test if an intervention used to manipulate memory and inference can improve our understanding of how brain development supports these abilities in healthy adolescent and adult volunteers. The main questions it aims to answer are: (1) Do hippocampus and ventromedial prefrontal cortex shift from forming simple memories for singular experiences to more complex memories that link numerous experiences together?; (2) Does an improved ability to retrieve prior memories in parietal cortex during new learning have consequences for how those memories are organized at different ages?; and (3) Does the emerging memory control supported by ventromedial prefrontal cortex development facilitate the formation of optimally-organized memory representations? Adolescent participants (13-18 years) will perform two experimental tasks during functional magnetic resonance i

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📋 Eligibility rules (as published)
Inclusion Criteria: * Right-handed * Have normal or corrected to normal vision * Have normal hearing * Do not have contraindications for MRI * Have no history of neurological or psychiatric disorders at initial intake * Are of normal intelligence * Native or fluent English speaker Exclusion Criteria: * A major medical illness or a neurological disorder, or neurological abnormality including significant head trauma (loss of consciousness \> 5 min). * Meeting criteria for any psychiatric disorder or any prior psychiatric hospitalizations * Intelligence scores more than 1 standard deviation below the mean on the WASI-II * History of special education placement * Non-native English speaker * Prior use of psychotropic medication, except antidepressants, for longer than 1 month * History of moderate to severe cannabis use disorder, via self-report * MRI exclusions: Claustrophobia; tattoos above the shoulders; permanent eyeliner; permanent retainer or spacer; artificial eyebrows; cardiac pacemaker; metal fragments in eye, skin, or body, including shrapnel; heart valve replacement; brain clips; venous umbrella; being a sheet-metal worker or welder; lifetime history of aneurysm surgery; intracranial bypass, renal, or aortic clips; prosthetic devices such as middle ear, eye, joint, or penile implants; joint replacements; non-removable hearing aid, neurostimulator, or insulin pump; shunts/stents; metal mesh/coil implants; metal plate/pin/screws/wires; or any other metal implants; or suspected pregnancy.
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What it tests

  • Associative Inference
  • Probabilistic Inference
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Where

1 site
The University of Texas at Austin
Austin, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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