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Prepare the Mind: Can Coaching in Goal-directed Behaviour Increase the Success of Cognitive Rehabilitation in People With MS?

RecruitingNAAges 18 Years - 65 YearsAllUniversiteit Leiden
NCT07225868 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

People with Multiple Sclerosis (MS) often experience cognitive difficulties such as memory problems, concentration issues, and reduced processing speed. These symptoms can have a negative impact on daily functioning and overall quality of life. Previous research on cognitive rehabilitation has shown that regular training focused on memory and concentration can have positive effects on cognitive functioning, including processing speed, memory, and executive functions that support daily activities. Moreover, fMRI studies (brain scans that measure brain activity) have revealed changes in brain activation following cognitive rehabilitation. Recently, the idea has emerged that a more personalized approach could improve treatment outcomes. Specifically, researchers have identified a link between personality traits and cognitive functioning. Since every individual is different, current cogniti

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📋 Eligibility rules (as published)
Inclusion Criteria: * Confirmed relapsing remitting or secondary progressive MS diagnosis according to the McDonald 2017 criteria * Expanded Disability Status Scale (EDSS) score \< 7 * Relapse free period ≥ 3 months * Unchanged disease modifying therapy for ≥ 2 months at time of inclusion * Age 18-65 years * Language Dutch, English or German for each centre respectively Exclusion Criteria: * High conscientiousness, measured with a T score 65 or higher on the BFI-2 subscale for conscientiousness * Current or prior brain trauma or neurological condition (other than MS) * Psychiatric disorder that heavily impacts cognitive and/or daily functioning * Medication intake and/or substance abuse that has an influence on cognitive functioning * For Dutch subsample undergoing MRI: Contradiction for MRI
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What it tests

  • Conscientiousness Coaching Before Cognitive Rehabilitation
  • Sham Intervention Before Cognitive Rehabilitation
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Where

3 sites
Jacobs School of Medicine and Biomedical Sciences, Neurology, University at Buffalo
Buffalo, United States
Health, Medical and Neuropsychology, Institute of Psychology, Faculty of Behvavioural and Social Siences, Leiden University
Leiden, Netherlands
Research Department, Reha Rheinfelden
Rheinfelden, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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