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Clinical Trial in Hypertensive Patients Comparing Two Cardiorespiratory Exercise Protocols, Low-volume Sprint Interval Training (SIT) Versus Moderate-intensity Continuous Training (MICT), to Evaluate Decreases in Ambulatory Blood Pressure and Other Clinical Variables.

RecruitingNAAges 30 Years - 59 YearsAllUnidad Enfermedades Cardiometabolicas- Hospital I…
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In plain words

What the trial is, and whether it could suit you

This randomized clinical trial aims to compare two cardiorespiratory exercise training protocols - Sprint Interval Training (SIT), characterized by short, maximal-intensity efforts, versus Moderate-Intensity Continuous Training (MICT) - in patients with arterial hypertension. The primary objective is to evaluate the impact of both interventions on 24-hour ambulatory systolic blood pressure (ABPM) after a 12-week training period. Secondary outcomes include diastolic, daytime, and nighttime blood pressure, metabolic and hemodynamic parameters, body composition, and serum myokine levels (IL-6 and α-CGRP). Participants aged 30-59 years with diagnosed hypertension but without high cardiovascular risk will be recruited from the Cardio-Metabolic Disease Unit of Hospital San Martín (La Plata, Argentina). After a two-week familiarization period, eligible participants will be randomized to SIT o

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients of both sexes between 30-59 years of age who meet the definition of hypertension. Hypertension will be defined as: 1. Those patients who report a history of hypertension and are under pharmacological treatment for it (Angiotensin Converting Enzyme Inhibitors/Angiotensin II Receptor Antagonists/Calcium Channel Blockers/Thiazide Diuretics/Beta Blockers) at the time of the evaluation. OR 2. Patients who report a history of hypertension during the evaluation and who, without pharmacological treatment, have average levels ≥140/90 mmHg will also be considered hypertensive. Exclusion Criteria: * Extreme body mass index (BMI) \<18.5 and ≥35. * Patients with office blood pressure readings ≥160/100 mmHg. * Patients with high cardiovascular risk conditions such as type II diabetes, chronic kidney disease (\<60 milliseconds), history of cerebrovascular disease, coronary artery disease, peripheral arterial disease, or heart failure (Framingham Criteria clinical diagnosis). * Pregnant or postpartum women up to 3 months old. * Patients with psychophysical limitations that make exercise difficult. * Patients with a history of active malignant neoplastic disease under treatment. Elimination Criteria -Patients whose pharmacological treatment is initiated or modified during the follow-up after 3 months.
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What it tests

  • SIT group: 2-4 maximal 20-30-second cycling sprints (≥100% VO₂max) with recovery intervals (2-4 min), total duration ≤15 minutes per session.
  • MICT group: Continuous cycling at 50-70% of VO₂max, 15-30 minutes per session.
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Where

1 site
Hospital Interzonal General San Martin La Plata
La Plata, Argentina
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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