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Transthoracic Drainage of Lung Abscesses. A National Randomized Trial.

RecruitingNAAges 18 Years - anyAllUniversity of Aarhus
NCT07247461 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to investigate if early drainage of lung abscesses, in addition to standard antibiotic treatment, leads to shorter length of hospital stay. Study Design This is a randomized, controlled clinical trial. That means participants will be randomly assigned to one of two groups: 1. Drainage group: Receives a chest tube (drain) inserted through the chest wall into the abscess in combination with standard intravenous antibiotics. 2. Control group: Receives standard intravenous antibiotics only Each participant has a 50/50 chance of being placed in either group. During Hospital Stay All participants will begin treatment with intravenous antibiotics (piperacillin/tazobactam). If assigned to the drainage group, a trained medical team will insert a small tube into the abscess to drain the pus. The tube is flushed three times a day with sterile saline. Participants will also: *

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>18 years. * Signed informed consent. * CT scan compatible with LA (one or more cavitating lesions with liquid content). * Clinical findings suggestive of ongoing infection. * Lung abscess size ≥ 4 cm in diameter. * Imaging indicates that the abscess contains fluid. * The abscess involves the outer one-third of the lung. Exclusion Criteria: * Pregnancy. Prior to inclusion of fertile women, a negative pregnancy test must be available. * Brest feeding. * Predicted survival of less than 3 months. * Known tuberculosis or non-tuberculous mycobacteriosis. * Known chronic pulmonary aspergillosis. * Patients with a primary suspicion of lung cancer * Recent (\<3 months) contact with health facilities outside Scandinavia. * Patients in whom anticoagulant treatment cannot be discontinued, or in whom the treatment pause does not allow drainage within 72 hours. * Coagulopathy or other increased bleeding risk that cannot be corrected to allow drainage within 72 hours. * Hemodynamic and/or respiratory unstable patient.
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What it tests

  • Transthoracic drainage
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Where

1 site
Aarhus Universitets Hospital
Aarhus, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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