🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Oral-Spray Bacillus Spore Probiotics for Periodontal Disease Prevention and Supprotive Treatment in the Elderly

RecruitingNAAges 35 Years - anyAllAnabio R&D
NCT07258303 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Periodontal diseases are strongly associated with dysbiosis of the oral microbiome within the biofilm. Key pathogens, including Streptococcus mutans, Aggregatibacter actinomycetemcomitans, and Porphyromonas gingivalis, contribute to caries progression and periodontal inflammation. Given the limitations of antibiotic use and their potential side effects, probiotics represent a promising biological approach to restore microbial balance and support oral health. In this study, researchers propose that direct application of probiotic spray into the oral cavity is safe and effective in alleviating typical symptoms of periodontal disease, particularly by reducing pathogenic bacterial density. The objective of this study is to evaluate the safety and efficacy of a oral-spray Bacillus spore probiotics (LiveSpo Smile CARE), containing Bacillus subtilis ANA48 and Bacillus clausii ANA39 at a conce

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria * Patients aged 35 years and older. * Patients diagnosed with periodontal disease based on clinical examination, including gingivitis and periodontitis. * Patients presenting with at least 10 natural teeth in the dental arch. * Patients with stable general health status and able to comply with study procedures. * Patients (or their legal guardians) who provide written informed consent and voluntarily agree to participate in the study. Exclusion Criteria * Patients with unstable general health, acute systemic or oral diseases, or malignant conditions that may interfere with participation. * Patients who are currently receiving treatment for periodontal disease at specialized dental facilities. * Patients currently using any therapeutic or adjunctive products for the management of periodontal disease.
💊

What it tests

  • oral-spray 0.9% NaCl physiological saline solution
  • LiveSpo Smile CARE
📍

Where

1 site
Tuyet Thai Senior Care Center
Hanoi, Vietnam
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy