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A Study of LY4213663 in Healthy Participants and Participants With Rheumatoid Arthritis

RecruitingPhase 1Ages 18 Years - 75 YearsAllEli Lilly and Company
NCT07258849 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to evaluate how well LY4213663 is tolerated and what side effects may occur in healthy participants and participants with rheumatoid arthritis (RA). The study drug will be administered either subcutaneously (SC) (under the skin) or intravenously (IV) (into a vein in the arm). Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. The study will last approximately 33 weeks excluding screening.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Have a body mass index (BMI) of 18.0 to 32.0 kilogram per square meter (kg/m²), inclusive Part C and D Only: * Have a body weight at least 50 kilograms and BMI within the range 18.0 to 40.0 kg/m² (inclusive) at screening * Have a diagnosis of adult-onset RA for at least 3 months prior to screening Exclusion Criteria: Healthy Participants for SAD Part A and MAD Part B Only: * Have a history or presence of cardiovascular, respiratory, hepatic, ophthalmological, renal, gastrointestinal, endocrine, hematological, neurological, or psychiatric disorders capable of significantly altering the absorption, metabolism, or elimination of drugs Participants with RA for Parts C and D Only: * Have Class 4 RA according to American College of Rheumatology (ACR) revised criteria * Have a 12-lead electrocardiogram (ECG) abnormality at screening * Have a current or recent acute active infection
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What it tests

  • LY4213663
  • LY4213663
  • Placebo
  • Placebo
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Where

10 sites
Pinnacle Research Group, LLC
Anniston, United States
Arizona Research Center
Phoenix, United States
Clinical Research of West Florida, Inc. (Clearwater)
Clearwater, United States
GNP Research at Mark Jaffe, MD
Cooper City, United States
Fortrea Clinical Research Unit
Daytona Beach, United States
AGA Clinical Trials
Hialeah, United States
Advanced Pharma CR, LLC
Miami, United States
Floridian Clinical Research
Miami Lakes, United States

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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