AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Methionine Intake Microbiota

RecruitingNAAges 20 Years - 50 YearsAllCentre hospitalier de l'Université de Montréal (C…
💬

In plain words

What the trial is, and whether it could suit you

Pro-inflammatory immune cells play a pivotal role in multiple sclerosis, and the gut microbiota is increasingly recognized as a key factor shaping the immune system. This study aims to determine the impact of a dietary intervention (methionine-restricted diet-MR) on gut microbiota and inflammation in humans. A randomized interventional pilot study with cross-over intervention is conducted in 40 healthy participants. For all participants, the first two weeks (week 1+week 2) consist of baseline assessment on their usual diet, and week 3+week 4 consist of MR diet only. For group A, the week 5+week 6 are MR+1,500 mg daily supplementation of methionine and for group B are MR+placebo, with a cross-over for week 7+week 8. Usual diet is resumed for all participants during week 9+week 10. Gut microbiota, blood levels of methionine and its metabolites, as well as immune and inflammatory markers wi

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy adults * 20-50 years old * On omnivorous/western diet * Understanding French or English Exclusion Criteria: * B12 deficiency * Glomerular filtration rate \<75 ml/h * Liver dysfunction * Pregnant or lactating * Active inflammatory or infectious disease * Insulino-dependent diabetes * Active cancer * Eating disorder * BMI \< 18.5 kg/m2 * Severe food allergies or intestinal problems or active substance dependence that would prevent adherence to the experimental diet
💊

What it tests

  • Methionine-restricted diet
📍

Where

1 site
Centre de recherche du Centre Hospitalier de l'Université de Montréal
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy