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High-intensity Resistance Training in Post-exacerbation COPD

RecruitingNAAges 18 Years - anyAllIstituti Clinici Scientifici Maugeri SpA
NCT07302425 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

After a COPD exacerbation, many individuals experience severe weakness in the leg muscles, especially the quadriceps. This weakness can make daily activities difficult and slow down recovery. Traditional respiratory rehabilitation usually focuses on endurance training, which is effective but often hard to tolerate soon after an exacerbation due to persistent symptoms and limited functional capacity. This study aims to compare two early rehabilitation approaches during recovery from a COPD exacerbation: a maximal strength training (MST) programme using high loads and few repetitions, and a traditional endurance-based training programme. The investigators aim to determine whether MST is easier to tolerate, especially in terms of breathlessness, and whether MST can improve muscle strength, efficiency, and overall exercise tolerance as well as or better than endurance training. The result

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📋 Eligibility rules (as published)
Inclusion Criteria: * COPD diagnosis according to the GOLD guidelines \[11\] with FEV1/FVC \<70% * Stable clinical condition (pH\>7.30) \[11\] * Hospital discharge within 3 weeks from an event of hospitalization due to an acute exacerbation of COPD. * Absence of significant motor disability, described by the possibility of performing the 6MWT. Exclusion Criteria: * Presence of lung diseases other than COPD * Orthopedic and neurological conditions that prevent the execution of functional tests * Severe neurological and cardiologic comorbidities or other severe diseases compromise exercise tolerance. * Cognitive impairment evaluated by Mini-Mental State Examination (MMSE) score as \< 25.
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What it tests

  • HIRT
  • HIET
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Where

1 site
ICS Maugeri IRCCS, Respiratory rehabilitation of the Institute of Lumezzane
Lumezzane, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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