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Enhanced Molecular Microbiological Surveillance Versus Ceftriaxone Prophylaxis in Hematopoietic Cell Transplant Patients

RecruitingNAAges 18 Years - anyAllPomeranian Medical University Szczecin
NCT07308457 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn whether close microbiological monitoring without preventive antibiotics works as well as preventive treatment with ceftriaxone in adults receiving stem cell transplants. The study focuses on people with blood cancers or other conditions who need either autologous or allogeneic hematopoietic stem cell transplantation (HSCT). The main questions the study aims to answer are: What percentage of participants develop an infection when they do not receive preventive antibiotics compared with those who receive daily ceftriaxone? Does preventive ceftriaxone lower the chance of specific complications such as bloodstream infections, pneumonia, or severe sepsis? Researchers will compare two groups: one group will not receive preventive antibiotics one group will receive ceftriaxone once a day until their white blood cells recover or until signs of in

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📋 Eligibility rules (as published)
Inclusion Criteria: * Recipient of autologous or allogeneic hematopoietic stem cells from peripheral blood, bone marrow, or cord blood. * Age ≥18 years. * Ability to provide written informed consent. * No active infection for at least 2 weeks prior to transplantation. Exclusion Criteria: * Controlled fungal infection. * Fever of unknown origin. * Ongoing antibiotic therapy (except cotrimoxazole). * Participation in any clinical study or experiment at the time of inclusion.
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What it tests

  • Ceftriaxone 1000 MG
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Where

1 site
Uniwersytecki zpital Kliniczny nr 1 im. prof. Tadeusza Sokołowskiego Pomorskiego Uniwersytetu Medycznego w Szczecinie
Szczecin, Poland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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