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Topical Application of Engineered Lactobacillus Reuteri With a Zinc Sulfate-Tannic Acid MPN Coating for Acne

RecruitingPhase 2Ages 18 Years - 33 YearsAllShenzhen People's Hospital
NCT07366229 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A growing body of evidence suggests that the development and progression of acne are closely linked to an imbalance in the skin's microbial community. Compared to healthy skin, the composition and function of the microbiota in acne lesions are significantly altered. This microbial imbalance is believed to drive the formation and recurrence of acne through mechanisms such as triggering abnormal inflammatory responses and compromising the skin barrier. An in-depth exploration of the interaction between acne and the skin microbiome not only offers new perspectives for understanding the root causes of the disease but also lays the groundwork for developing novel treatment strategies aimed at modulating the microbiota. Therefore, identifying innovative approaches that integrate acne treatment with the regulation of microbial balance holds significant clinical and social value. Although exis

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Subjects must be diagnosed with acne (based on history, clinical manifestation, and dermatoscopy) and classified as Grade I to III per the International Improved Grading System. 2. Subjects must be willing and able to provide written informed consent. 3. Subjects must be 18 to 33 years of age and in generally good health. 4. Subjects must have more than 9 inflammatory lesions. Exclusion Criteria: 1. Have used antibiotics within 1 month before the study start. 2. Have used systemic retinoid therapy within 3 months before the study start. 3. Have undergone any other acne treatment within 1 month before the study start. 4. Have any other condition that the investigator considers would make participation unsuitable (e.g., deemed unreliable, non-compliant, or unable to comprehend the study assessments).
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What it tests

  • MPN-coated engineered Lactobacillus reuteri cream
  • Plain Lactobacillus reuteri cream
  • Petrolatum-glycerin cream
  • Tretinoin cream 0.1%
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Where

1 site
Shenzhen People's Hospital
Shenzhen, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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