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The Acute Effect of Exercise Type And Timing on Ambulatory Blood Pressure and Intra-Ocular Pressure in Individuals With Glaucoma (The ACHIEVE-project).

RecruitingNAAges 18 Years - anyAllKU Leuven
NCT07413614 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

ACHIEVE aims to determine whether exercise can be a safe and effective non-drug approach to improve blood pressure control in patients with primary open-angle glaucoma (POAG). Although exercise is a promising and potentially well-accepted therapy, its use in clinical care is limited because the safety and effectiveness of different exercise types (aerobic, isometric, moderate, or high intensity) and timing (morning versus evening) have not been systematically studied in people with POAG and elevated blood pressure. This study will evaluate the safety and short-term effects of different exercise modalities and timings on 24-hour ambulatory blood pressure and blood pressure variability in patients with POAG and elevated blood pressure. It is hypothesized that: * Each exercise session will lead to a temporary reduction in blood pressure (post-exercise hypotension). * The greatest and lon

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📋 Eligibility rules (as published)
Inclusion Criteria: * Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures * At least 18 years of age at the time of signing the Informed Consent Form (ICF) * Patients with POAG AND \[elevated BP OR hypertension (Average SBP on Home BP ≥120 mmHg AND/OR Average DBP on Home BP ≥70 mmHg) with or without the use of anti-hypertensive medication\] * Patients without recent changes in medication and glaucoma care within the past four weeks. Exclusion Criteria: * Not able to provide informed consent * SBP and/or DBP are ≥ 150 mmHg and/or ≥ 95 mmHg, respectively, on office BP at screening AND on home BP measurement conducted in the week following screening (to identify White Coat Hypertension) to ensure safety. These patients require referral for early treatment. * Aberrant cardiopulmonary exercise test (CPET) at screening (Life-threatening arrhythmias, ischemia,…) * Unable to perform one or more of the four exercise sessions due to physical and or mental limitations (severe lung disease, musculoskeletal issues, unstable angina,…) * Severe osteoarthritis pending knee replacement surgery (these patients may be unable to perform the IRE (i.e. wall squat exercise) * Unable to communicate in Dutch * Active malignancy * Participation in an interventional Trial with an investigational medicinal product (IMP), exercise intervention or device * Unwillingness to repeat ABPM * Relative contraindications to ABPM: diagnosed atrial fibrillation, nighttime workers, occupational drivers
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What it tests

  • Exercise
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Where

1 site
UZ Leuven/KU Leuven
Leuven, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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