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A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies

RecruitingPhase 2Ages 18 Years - anyAllMirati Therapeutics Inc.
NCT07415031 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit. * Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF. Exclusion Criteria: * Participant is not eligible for study treatment per the parent study eligibility criteria. * Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study. * Participants not receiving clinical benefit from parent study drug as assessed by the investigator. Other protocol defined inclusion/exclusion criteria applies.
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What it tests

  • Adagrasib
  • Pembrolizumab
  • Cetuximab
  • Pemetrexed
  • Docetaxel
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Where

101 sites
Local Institution - 0005
Phoenix, United States
Southern California Permanente Medical Group
Bellflower, United States
MemorialCare - Long Beach Medical Center
Long Beach, United States
Local Institution - 0003
Newark, United States
Florida Cancer Specialists - North
St. Petersburg, United States
Cancer Center of Kansas
Wichita, United States
Local Institution - 0092
Boston, United States
Local Institution - 0080
Boston, United States

…and 93 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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