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Mechanical Insufflation-Exsufflation in Critically Ill Patients

Recruitingn/aAges any - anyAllMedipol University
NCT07420946 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Mechanical insufflation-exsufflation (MI-E) is an established airway clearance technique for patients with chronic conditions like neuromuscular diseases. However, its use in critically ill ICU patients remains inconsistent and lacks standardized guidelines. Despite growing research, current practices vary widely in patient selection, treatment protocols, and safety management, with limited high-quality evidence to support clear recommendations. To address this gap, an international, multidisciplinary Delphi consensus study is needed to establish expert-based best practices and feasible guidelines for the safe and effective implementation of MI-E in the intensive care setting.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthcare professionals with documented clinical experience in critical care medicine, pulmonology, anesthesiology, respiratory therapy, or physiotherapy with involvement in airway clearance strategies. * Demonstrated experience or recognized expertise in the clinical use of MI-E, either in critically ill patients or in patients with complex respiratory conditions. * A minimum of 5 years of clinical experience in their respective field, or a proven academic or clinical contribution related to MI-E. * Willingness to participate in multiple Delphi rounds and to provide informed consent. * Ability to complete the questionnaires in English. Exclusion Criteria: * Lack of direct clinical or academic experience related to MI-E or airway clearance techniques. * Inability or unwillingness to provide informed consent. * Failure to complete the first Delphi round after formal invitation and consent. * Withdrawal of consent at any stage of the Delphi process.
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What it tests

  • Delphi Questionnaire
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Where

4 sites
Monaldi Hospital A.O.R.N. dei Colli
Naples, Italy
University of Naples Federico II
Naples, Italy
Hospital General Universitario Morales Meseguer
Murcia, Spain
İstanbul Medipol University
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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