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Vitamin D for Acute Intracerebral Hemorrhage

RecruitingNAAges 18 Years - 90 YearsAllThe University of Hong Kong
NCT07458815 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Intracerebral hemorrhage (ICH) is the most deadly and debilitating form of stroke. To date, effective treatment that could improve the functional outcome of ICH remained elusive. In a mice model of ICH, it was demonstrated that high dose Vitamin D (VitD) treatment enhanced hematoma resolution by promoting reparative macrophage differentiation and improved neurobehavioral performance in mice. Hence, this pilot study aimed to investigate the feasibility and safety of VitD treatment for ICH in human subjects. VICToHR is a prospective, randomized, open-label, blinded-endpoint (PROBE) trial. Participants will be randomized 1:1 to receive either VitD or standard care (control). The intervention group will receive VitD 4000 IU daily for 2 weeks, followed by 1000 IU daily for 24 weeks. The primary outcomes are the rate of hematoma resolution at 14 days and the incidence of hypercalcemia and Vit

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📋 Eligibility rules (as published)
Inclusion Criteria: * Spontaneous ICH diagnosis * Age ≥ 18 years * Within 96 hours of ICH * Premorbid Modified Rankin Scale of ≤2 * Supratentorial ICH * ICH volume ≥2 mL Exclusion Criteria: * Expected life expectancy of \<1 year * Glasgow Coma Scale \<9 * Anticipated surgical evacuation of hematoma * Inability to participate in follow-up activity * Hypercalcemia * Hyperphosphatemia * History of kidney stones * Bleeding tendency * Severe renal impairment * Severe liver impairment * Known contraindication or allergy to vitamin D
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What it tests

  • Vitamin D
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Where

1 site
The University of Hong Kong
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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