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Effects of Cranberry on Gut and Metabolic Health

RecruitingNAAges 25 Years - 70 YearsAllLaval University
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In plain words

What the trial is, and whether it could suit you

The consumption of plant-based foods, particularly berries, has been associated with improved health due to their high content of bioactive compounds. Among these, polyphenols-especially proanthocyanidins (PACs)-may offer protective effects against chronic diseases related to overweight and obesity. Cranberries are naturally rich in PACs and may positively influence metabolic health by modulating the gut microbiota. However, their specific effects on intestinal integrity and broader metabolic outcomes remain underexplored. The primary aim of this study is to assess the effects of cranberry supplementation on glucose metabolism, insulin sensitivity, blood lipid levels, and the composition and function of the gut microbiota in overweight and obese individuals. This randomized, double-blind, placebo-controlled, crossover clinical trial will include two 12-week intervention periods-one wit

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📋 Eligibility rules (as published)
Inclusion Criteria: * body mass index between 25 and 40 kg/m2 * at least one of the following criteria: fasting plasma insulin \>60 pmol/L, fasting glycemia between 5.5 and 6.9 mmol/L, glycated hemoglobin (HbA1c) level of 5.7- 6.4% and/or fasting triglyceride \>1.35 mmol/L. Exclusion Criteria: * to have aversion to cranberry products * regularly drinking alcohol (\>2 glasses/day) * having a significant change in body weight in the past 3 months (±5% of their body weight) due to bariatric surgery or other conditions * taking medication which may affect the study outcomes (i.e. antidiabetic and/or cholesterol or lipid-lowering medications and/or glucocorticosteroid in supraphysiological doses and/or anti-obesity medications) * taking regular probiotics and prebiotics (including fruit/berry polyphenol supplements) in the past 3 months * having eating disorders * had undergone major surgery 3 months prior to the study or if they had one planned * if they had intestinal malabsorption, cirrhosis or chronic kidney disease * being pregnant, planning a pregnancy, or breastfeeding.
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What it tests

  • Cranberry beverage
  • Placebo beverage
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Where

1 site
INAF, Université Laval
Québec, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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