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STATIC - Statin Termination in Cancer

RecruitingNAAges 18 Years - anyAllStiftelsen Stockholms Sjukhem
NCT07543432 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

There are many guidelines on when to start drug treatment, but surprisingly few guidelines on how and when to stop drugs. For example, there are currently no clear guidelines on when to stop preventive medications such as statins in patients in palliative cancer care. According to previous studies, these drugs are often deprescribed far too late in the process, often close to death. This can lead to unwanted side effects, such as muscle weakness, increased fatigue, and also contribute to unnecessary drug costs and unnecessary environmental impact. In the STATIC I study the safety and effects of early deprescribing of statins in palliative cancer care is explored. The primary aim of the STATIC study is to study the change in LDL-levels (mmol/L) after statin termination. The secondary outcomes includes change in levels of other steroids (cholesterol, HDL, Q10, 25-hydroxyvitamin D, lanoste

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria intervention arm: * ≥ 18 years, * "No"-answer to the "surprise question" 1 year: Would you be surprised if this patient died in the next year? (this is a common and validated prognostic tool in palliative care) * advanced cancer * ongoing palliative care at the the unit study units * treatment with statins ≥ 3 months for primary or secondary prevention before study inclusion Inclusion Criteria control-group: * Same as above but no statin treamnet Exclusion Criteria:h * Cognitive impairment * Does not understand the Swedish language * Known homozygous or double heterozygous familial hypercholesterolemia * Active cardiovascular disease or sufficient risk of active cardiovascular disease that requires ongoing medication with statins (assessed by a specialist in cardiology) * myositis symptoms * Other contraindications to deprescribe statins.
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What it tests

  • Deprescribing statins
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Where

2 sites
Stockholms Sjukhem Pallitive Care
Stockholm, Sweden
ASIH Stockholm Södra
Stockholm, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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