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Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis

RecruitingNAAges 18 Years - anyAllAl-Mustansiriyah University
NCT07547202 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis. Periodontitis is a chronic inflammatory disease that destroys tooth-supporting tissues. Smoking is a significant risk factor that worsens periodontal destruction and reduces the effectiveness of standard therapies. * The trial is a non-randomized comparative clinical study. * It includes 44 adult patients diagnosed with Stage II and III periodontitis. * The participants are divided into two equal groups: 22 current smokers and 22 non-smokers. * Participants will undergo a baseline examination, followed by standardized non-surgical periodontal therapy consisting of scaling and root planing. * A follow-up visit will be conducted six weeks post-therapy to repeat clinical measurements and saliva collect

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📋 Eligibility rules (as published)
Inclusion Criteria: * Systemically healthy. * Diagnosed with Stage II and III periodontitis. * Presence of ≥ 20 teeth (excluding third molars). * Current smoker OR non-smoker Exclusion Criteria: * Presence of systemic diseases affecting the periodontium. * Use of medications affecting inflammation. * Received periodontal therapy in the past 6 months. * Received antibiotic therapy in the last 3 months. * Alcohol use.
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What it tests

  • Non-surgical periodontal therapy (Scaling and root planing)
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Where

2 sites
Al-Sadr Specialized Dental Center
Baghdad, Iraq
Sadr Specialized Dental Center
Baghdad, Iraq
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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