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Colchicine for Autoimmune and Subacute Thyroiditis

RecruitingPhase 2, Phase 3Ages 18 Years - 70 YearsAllMansoura University
NCT07571681 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Thyroiditis includes inflammatory thyroid disorders such as Hashimoto's thyroiditis and subacute thyroiditis. These conditions may cause thyroid pain, neck tenderness, elevated inflammatory markers, thyroid dysfunction, fatigue, and recurrence. Current management includes observation, symptomatic treatment, nonsteroidal anti-inflammatory drugs, and corticosteroids. Although corticosteroids may be effective, relapse after tapering and treatment-related adverse effects remain limitations. Colchicine is hypothesized to reduce inflammatory activity and may improve biochemical and clinical recovery. This study will evaluate the efficacy and safety of low-dose colchicine compared with corticosteroid therapy and supportive care in adults with autoimmune or subacute thyroiditis.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 to 70 years * Newly diagnosed Hashimoto's thyroiditis or Subacute thyroiditis * Diagnosis confirmed clinically, biochemically, and ultrasonographically * Ability to provide written informed consent Exclusion Criteria: * Pregnancy or breastfeeding * Severe renal impairment * Severe hepatic disease * Cytopenia * Active serious infection * Known hypersensitivity to colchicine * Chronic corticosteroid use within previous 30 days * Participation in another interventional trial * Any condition affecting safety or protocol adherence
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What it tests

  • colchicine
  • Prednisolone
  • NSAID
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Where

2 sites
Mansoura University
Al Mansurah, Egypt
Saudi German Hospital
Jeddah, Saudi Arabia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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