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Overcoming the Barriers to Effective Transcranial Temporal Interference Stimulation in Humans

RecruitingNAAges 18 Years - 65 YearsAllNortheastern University
NCT07593859 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Transcranial temporal interference stimulation (TIS) is an emerging novel tool for non-invasive transcranial brain stimulation that holds the potential for focal and steerable neuromodulation, and the possibility to stimulate focally at depth. TIS involves combining two high frequency waveforms to create a waveform with a "beat" frequency that is physiological relevant for neuromodulation. Successful applications to deep brain targets as well as steerability of the stimulation focus have been demonstrated in mice. Numerous recent investigations in humans have shown great clinical potential for this technology, however several questions about the basic mechanism of TIS action remain. The investigators will apply TIS to the motor cortex of humans and use established transcranial magnetic stimulation techniques to assess cortical excitability in relation to the phase of the TIS waveform. Us

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📋 Eligibility rules (as published)
Inclusion Criteria: * Free of neurological or orthopedic conditions that may impact the ability to participate. * Right-hand dominant (self-reported) * Aged 18-65 years Exclusion Criteria: * Ferromagnetic metal implants in the brain/skull or elsewhere (dental implants excluded). * Any implanted electronic device (e.g. cardiac pacemaker, cochlear implant, deep brain stimulator, medication infusion pump; vagal nerve stimulator) * Diseased or damaged skin on face or scalp * History of migraines, fainting, seizures/epilepsy, or psychiatric illness * Neurological disorder or intracranial lesion * Frequent or severe headaches * Prior adverse reaction to transcranial magnetic stimulation * Currently pregnant * Suspected or diagnosed heart problems (e.g. arrhythmia, cardiac disturbances). * Insulin-dependent diabetes * Suspected or diagnosed epilepsy or a familial history of epilepsy * Use of alcohol or recreational drugs in the prior 12 hours * Use of prescription and over the counter medications will be grounds for exclusion except for: contraceptive (birth control) drugs (e.g. those containing ethinyl estradiol and/or norethindrone), and seasonal allergy medications (e.g. cetirizine (Zyrtec), fexofenadine (Allegra), and loratadine (Claritin)).
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What it tests

  • transcranial Temporal Interference Stimulation
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Where

1 site
Northeastern University
Boston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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