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Bronchoscopic Airway Clearance for Improving Lung Aeration in Mechanically Ventilated Patients With Atelectasis

RecruitingNAAges 18 Years - anyAllSoutheast University, China
NCT07594379 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn whether bedside flexible bronchoscopy-guided airway clearance can improve lung aeration in adult patients who are receiving invasive mechanical ventilation and have atelectasis with a high airway secretion burden. The main questions it aims to answer are: Does bedside flexible bronchoscopy-guided airway clearance reduce the proportion of nonaerated lung tissue from baseline to day 5? Does this treatment improve other lung aeration measures, respiratory mechanics, arterial blood gas parameters, pulmonary infection score, ventilator-free days, intensive care unit length of stay, and safety outcomes? Researchers will compare usual airway care plus bedside flexible bronchoscopy-guided airway clearance with usual airway care alone to see if bronchoscopy-guided airway clearance improves lung aeration and clinical outcomes. Participants will be ra

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age 18 years or older 2. Receiving invasive mechanical ventilation for at least 48 hours 3. Presence of atelectasis confirmed by chest computed tomography, chest X-ray, or lung ultrasound 4. High airway secretion burden, defined as requiring airway suctioning at least twice per hour during the previous 8 hours 5. Written informed consent obtained from the participant or legally authorized representative Exclusion Criteria: 1. Expected duration of artificial airway maintenance less than 5 days 2. Untreated tension pneumothorax 3. Large pleural effusions requiring thoracentesis. 4. Known or suspected aspiration 5. Active intrapulmonary hemorrhage 6. Severe dysfunction of other organs with expected short-term mortality within 7 days or need for palliative care 7. Any other condition judged by the medical team to make the participant unsuitable for the study 8. Informed consent not obtained
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What it tests

  • Flexible Bronchoscopy-Guided Airway Clearance
  • Usual Airway Care
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Where

1 site
Zhongda Hospital, Southeast University
Nanjing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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