Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy

Inclusion Criteria: 1. Age 18-85 years 2. Diagnosis of acute ischemic stroke 3. Pre-stroke mRS 0-1 4. Baseline NIHSS score ≥ 6 5. Time from symptom onset to start of endovascular procedure (puncture) \< 24 hours; onset time defined as "last known well" time 6. Imaging criteria: ASPECTS 3-5 on CT, or ASPECTS \> 5 with acute ischemic core volume (defined as rCBF \< 30% or ADC \< 620) ≥ 50 mL 7. Occlusion of the intracranial segment of the internal carotid artery or the middle cerebral artery (M1/M2), confirmed as the symptomatic culprit vessel 8. After thrombectomy, the culprit vessel is considered to be occluded by an embolus, and successful recanalization (mTICI 2b/3, i.e., ≥ 50% perfusion) is achieved 9. Written informed consent signed by the patient or a legal representative Exclusion Criteria: 1. Presence of stenosis (≥ 50%) in the ipsilateral middle cerebral artery, internal carotid artery, or common carotid artery proximal to the occlusion site 2. Multiple emboli across different circulations (simultaneous anterior and posterior circulation emboli, or simultaneous left and right anterior circulation emboli) 3. Evidence on CT of extensive cerebral edema, midline shift, significant mass effect, or signs of brain herniation 4. Presence of a life-threatening disease with a prognosis \< 6 months, making 3-month follow-up impossible 5. Severe psychiatric disorder or heart failure 6. Concurrent participation in another clinical drug or device study 7. Any other condition that, in the investigator's judgment, makes the subject unsuitable for this study