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A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of ABS-1230 in Pediatric and Young Adult Participants With KCNT1-related Epilepsy

RecruitingPhase 2Ages 1 Month - 21 YearsAllActio Biosciences, Inc.
NCT07600736 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This trial will evaluate the safety, tolerability, pharmacokinetics, and clinical activity of ABS-1230 compared with placebo in participants with KCNT1-related epilepsy

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 1 month to \<22 years * Clinician-confirmed diagnosis of KCNT1-related epilepsy * Has an average of at least 4 countable motor seizures per week * Is taking no more than 6 antiseizure medications (ASM) and is able to keep stable doses of ASMs for the duration of Part 1 or Part 2 Exclusion Criteria: * Is currently taking phenytoin, carbamazepine, stiripentol, or quinidine * Has a medical condition that, in the opinion of the investigator, would limit the participant's ability to participate in the study or might compromise participant safety or interfere with evaluation of the study drug.
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What it tests

  • ABS-1230
  • Placebo
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Where

2 sites
Northeast Regional Epilepsy Group
Hackensack, United States
University of Rochester Medical Center
Rochester, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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