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Photobiomodulation Effects on Fatigue and Muscle Damage Induced by NMES

RecruitingNAAges 18 Years - 45 YearsAllFederal University of Rio Grande do Sul
NCT07602933 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Neuromuscular electrical stimulation (NMES) is widely used to improve muscle strength and mitigate atrophy. However, its clinical efficacy is often limited by early neuromuscular fatigue, muscle damage, and discomfort, which reduce patient tolerance and contraction time. Photobiomodulation (PBM) has emerged as a potential therapy to enhance muscle performance and accelerate recovery by minimizing fatigue and damage. Despite its potential, few studies have investigated the effects of PBM applied specifically before an NMES-evoked fatigue protocol. This randomized, double-blind, placebo-controlled trial aims to evaluate the acute effects of PBM on neuromuscular fatigue, muscle damage, and functional outcomes in healthy young subjects. Participants will receive either active PBM (cluster probe: 5 lasers 810nm/200mW; 4 LEDs 660nm/10mW; Total Energy: 249.6 J per limb) or sham treatment 5 minu

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy male and female volunteers. * Age between 18 and 45 years. * Practice physical activity regularly * No history of musculoskeletal injuries in the lower limbs in the last 6 months * Ability to tolerate NMES Exclusion Criteria: * Have sensory intolerable changes due to NMES * Consumed coffee or another stimulant in the last 12 hours * Have a body mass index (BMI) greater than 30 kg/m2 (grade I obesity) * Present any contraindication for the performance of maximum effort * Abnormal increase in blood pressure after maximal exertion
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What it tests

  • Active Photobiomodulation
  • Placebo Photobiomodulation
  • NMES-evoked fatigue protocol
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Where

1 site
Laboratório de Pesquisa do Exercício
Porto Alegre, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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