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โ† Trials
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Impact of rTMS on Abnormal Cortical fMRI in Patients With Dystonia

RecruitingNAAges 18 Years - 80 YearsAllNorthwell Health
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In plain words

What the trial is, and whether it could suit you

By tracking resting-state fMRI scans, we aim to discover how repetitive transcranial magnetic stimulation (rTMS) changes brain connectivity in individuals with dystonia.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Male or female * 18 and 80 years of age. * Patients who manifest dystonia - sustained involuntary movement of the head, neck, trunk or limbs. * The dystonia may be spontaneous or genetic, specifically DYT1 or DYT6 and then only those patients who are demonstrating dystonia. The patient/subject will have a normal neurological exam except for dystonia. Exclusion Criteria: * Heredodegenerative dystonia of the type DYT8,9 or 10. * Past history of head trauma, stroke, epilepsy, demyelinating disease * Hypertension in excess of 160mmHg systolic and 90mmHg diastolic * Congestive heart failure * Diabetes * Past psychiatric conditions: e.g., depression * Systemic metabolic disease: e.g., Wilson's disease, progressive neurodegenerative disease (like supranuclear palsy or corticobasal ganglionic degeneration) * Magnetizable incorporated metal parts - like pacemakers * History or diagnosis of Parkinson's disease * Presence of myoclonus * No previous surgery for dystonia * Long term exposure to benzodiazepines, neuroleptics or anticonvulsants * No botulinum toxin within 12 weeks of baseline assessment and fMRI. * Moderate to severe cognitive impairment (judged by a minimental status of \<24.)
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What it tests

  • Transcranial Magnetic Stimulation
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Where

1 site
Northwell Health/Feinstein Institutes
Manhasset, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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