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Vascular Function in Adults With Down Syndrome

Recruitingn/aAges 18 Years - 35 YearsAllUniversity of Nevada, Las Vegas
NCT07630207 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Adults with Down syndrome (Ds) are often thought to have a lower risk of heart and blood vessel disease because they tend to have lower blood pressure (BP) and fewer heart attacks than people without Ds. However, recent research suggests that heart and blood vessel diseases, including stroke, are becoming a more common cause of death in adults with Ds as life expectancy increases. Despite these findings, studies examining heart and blood vessel health in adults with Ds have produced mixed results, making it difficult to determine their true risk and whether preventive strategies are needed. This study will investigate the health of blood vessels in adults with Ds and compare the results with those of adults without Ds. Healthy blood vessels are important because they help deliver blood and oxygen throughout the body. Changes in blood vessel function and stiffness can occur with aging and

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📋 Eligibility rules (as published)
Inclusion Criteria: * between 18 and 35 years old * generally healthy * sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day) Additionally, for the participants with Down syndrome: * diagnosis of Down syndrome trisomy 21 * normal thyroid function or stable thyroid function (and medications) for at least 6 months. Exclusion Criteria: * unresolved congenital heart disease; * atherosclerotic or other vascular disease (such as blood clot history or clotting disorders); * asthma or other pulmonary disease; * hypertension (defined as BP \>140/90 mmHg); blood pressure below 90/60 mmHg; * history of pre-syncope or syncope; * diabetes (defined as glycated hemoglobin (HbA1c) of \>7.5% or use of glucose-lowering medication); * severe obesity (defined as body mass index (BMI) \>40); * heart medications affecting heart rate, blood pressure, or arterial function, including blood thinners; anti-inflammatory medication, including Nonsteroidal anti-inflammatory drugs (NSAIDS); * current smoking; * currently pregnant or planning to become pregnant during the study period; * currently breastfeeding; * unable or unwilling to use an acceptable method of contraception during the study timeframe; * positive pregnancy test at screening.
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What it tests

  • Not listed
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Where

1 site
University of Nevada Las Vegas - UNLV
Las Vegas, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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