CRP Apheresis in Infarct-Related Cardiogenic Shock

Inclusion Criteria: * Cardiogenic shock complicating acute myocardial infarction with planned revascularization by percutaneous coronary intervention (PCI). * Cardiogenic shock defined as: * Systolic blood pressure \<90 mmHg for \>30 minutes or requirement of catecholamine infusion to maintain systolic blood pressure ≥90 mmHg, and * Signs of impaired organ perfusion (at least one of the following): Cold, clammy skin and extremities, Altered mental status, Oliguria with urine output \<30 mL/hour, Arterial lactate \>2 mmol/L * C-reactive protein (CRP) level ≥7 mg/L at baseline. * Age ≥18 years. * Informed consent provided by the participant or, if the participant is unable to consent, inclusion after assessment and documentation of the presumed patient's will by two physicians (one independent), with informed consent obtained as soon as possible. Exclusion Criteria: * Fever (body temperature \>38°C) or acute infection with fever within the last 14 days. * Chronic inflammatory disease. * Known history of severe hepatic failure. * Chronic kidney disease with creatinine clearance \<30 mL/min/1.73 m² prior to hospital admission. * Life expectancy \<12 months prior to cardiogenic shock. * Participation in another interventional clinical trial. * Pregnancy. * Resuscitation duration \>30 minutes. * Cardiogenic shock due to causes other than acute myocardial infarction. * Onset of cardiogenic shock \>12 hours before randomization. * Age \>80 years.