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Superoxide Dismutase Skin Spray for the Prevention of Acute Radiation Dermatitis in Head and Neck Cancer

RecruitingPhase 2Ages 18 Years - 80 YearsAllWest China Hospital
NCT07704372 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To evaluate the efficacy and safety of superoxide dismutase skin spray for the reducing the acute radiation dermatitis in patients with head and neck malignancies undergoing radiotherapy.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Histologically confirmed malignant tumors of the head and neck without distant metastasis. 2. Scheduled to undergo either postoperative adjuvant radiotherapy or definitive radiotherapy, with or without concurrent chemotherapy. 3. Age 18-80 years at the time of consent. 4. Eastern Cooperative Oncology Group (ECOG) performance status 0-2. 5. Signed informed consent form. 6. Adequate cognitive and reading abilities to complete the questionnaire. Exclusion Criteria: 1. Pre-existing skin disease or open wounds in the irradiation field. 2. Have a history of head and neck radiotherapy. 3. Autoimmune or connective tissue disorders affecting skin. 4. Known allergy to any component of study formulations. 5. Any condition that, in the investigator's judgment, would interfere with study participation or outcome assessment.
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What it tests

  • A topical superoxide dismutase skin spray
  • Placebo Spray
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Where

1 site
Sichuan University West China Hospital
Chengdu, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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