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Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis

Recruitingn/aAges 45 Years - anyAllGaziosmanpasa Research and Education Hospital
NCT07712419 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Knee osteoarthritis (KOA) is a leading cause of chronic pain and disability. Although genicular nerve block (GNB) is an effective treatment for many patients, treatment response varies considerably. Identifying imaging biomarkers that predict clinical response may improve patient selection and optimize treatment outcomes. This prospective observational study aims to evaluate whether the Sonographic Thigh Adjustment Ratio (STAR), calculated as anterior quadriceps muscle thickness divided by body mass index (BMI), and subcutaneous fat thickness are associated with pain relief following genicular nerve block in patients with symptomatic knee osteoarthritis. Ultrasound measurements will be obtained before the procedure, and clinical outcomes will be assessed during follow-up. The primary objective is to determine whether sonographic muscle parameters can predict treatment response after GNB

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥45 years. * Symptomatic bilateral knee osteoarthritis with Kellgren-Lawrence grade 3 or 4. * Visual Analog Scale (VAS) pain score ≥4 at rest or during movement. * Scheduled to undergo first ultrasound-guided genicular nerve block. * No intra-articular knee injection within the previous 3 months. * Considered unsuitable for or awaiting total knee arthroplasty. * Ability to provide written informed consent. Exclusion Criteria: * Inflammatory arthritis, rheumatoid arthritis, or crystal arthropathy. * Previous knee surgery or knee prosthesis. * Active local or systemic infection. * Anticoagulant therapy or bleeding disorders. * Contraindication to corticosteroids (including uncontrolled diabetes mellitus). * Allergy to study medications. * Neurological disorders causing neuropathic knee pain. * Dementia or inability to complete study assessments. * Additional interventional procedures or surgery during follow-up.
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What it tests

  • Ultrasound-Guided Genicular Nerve Block
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Where

1 site
University of Health Sciences Gaziosmanpaşa Physical Therapy and Rehabilitation Training and Research Hospital
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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