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Hyperpolarized 13C-MRI and Radiomics in Rectal Cancer

Recruitingn/aAges 20 Years - anyAllChang Gung Memorial Hospital
NCT07730541 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is testing new imaging and analysis methods to improve how doctors predict treatment response in rectal cancer patients receiving chemoradiotherapy. Current MRI scans sometimes miss complete tumor response, which can lead to unnecessary surgery. To address this, researchers will use a special MRI technique called hyperpolarized carbon-13 MRI, along with blood and tissue analysis (metabolomics) and advanced image feature analysis (radiomics). These tools can track how cancer cells use energy and how metabolism changes during treatment. The study will follow 30 rectal cancer patients at Chang Gung Memorial Hospital over 3 years. Patients will undergo standard MRI, colonoscopy, and advanced metabolic imaging before and after treatment. Results will compare patients whose tumors completely respond to therapy with those who do not. The goal is to see if metabolic changes detected

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients with biopsy proved rectal adenocarcinoma. 2. Patents will undergo neoadjuvant chemoradiation therapy (nCRT). 3. Patients more than 20-year-old. Exclusion Criteria: 2\. Contraindication to MRI study (e.g., claustrophobia or non-removable devices or implants that are incompatible with MRI). 3. Intercurrent illness that will affect the compliance of the patient during the MRI study (e.g., active infection, symptomatic congestive heart failure, uncontrollable angina, arrhythmia, psychiatric disorders, dyspnea, or diarrhea). 4. Severe hepatic dysfunction (alkaline phosphatase/aspartate aminotransferase/alanine aminotransferase \>20 × upper limit of normal \[ULN\] or bilirubin \> 10 × ULN). 5. Severe renal impairment (eGFR \<30 ml/min/1.73m2).
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What it tests

  • Hyperpolarized 13C-MRI (HP 13C-MRI)
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Where

1 site
Chang Gung Memorial hospital
Taoyuan, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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