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โ† Trials
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Prevalence of Mild Cognitive Impairment and Dementia in Patients Admitted to Non-neurological Rehabilitation Wards

RecruitingNAAges 45 Years - anyAllFondazione Don Carlo Gnocchi ETS
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In plain words

What the trial is, and whether it could suit you

Cognitive impairment is common among older adults hospitalized for non-neurological conditions but often goes unrecognized, particularly in rehabilitation settings where clinical attention is mainly focused on physical recovery. The COGinREHAB study is a multicenter, prospective, longitudinal interventional study conducted at three rehabilitation centers of the Fondazione Don Carlo Gnocchi in Italy (Florence and Milan). The study will enroll 384 patients aged 45 years or older who are hospitalized for at least 7-10 days in cardiac, pulmonary, or orthopedic intensive rehabilitation units, or in intermediate care units, for conditions unrelated to the nervous system. At admission, all participants undergo a clinical and cognitive screening visit. Patients whose screening results suggest possible cognitive impairment then undergo a more extensive neuropsychological evaluation. In those wi

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age โ‰ฅ45 years * Hospitalization for at least 7-10 days for a non-neurological condition, in cardiac, pulmonary, or orthopedic intensive rehabilitation units, or intermediate care units * Adequate fluency in the Italian language * Provision of written informed consent Exclusion Criteria: * Illiteracy * Severe, uncorrected visual impairment and/or hearing loss * Severe verbal communication deficit * Inability to remain seated for the duration of the assessment * Inability to use the dominant upper limb * Altered state of consciousness or alertness (e.g., delirium) * Severe scalp skin lesions or dermatitis precluding electrode application for neurophysiological recordings * Previous or current history of severe psychiatric disorders (e.g., psychotic disorders, bipolar disorder, severe major depressive disorder with psychotic symptoms, current suicidal risk, or other psychiatric conditions judged by the investigator to interfere with study participation, procedural compliance, or interpretation of results) * Previous history or current presence of clinically relevant neurological pathologies other than cognitive impairment (e.g., epilepsy, stroke, neurodegenerative diseases such as Parkinson's disease or multiple sclerosis, moderate-to-severe traumatic brain injury, brain tumors, central nervous system infections, or other neurological conditions that may influence cognitive, behavioral, or neurological functioning, or otherwise compromise the study objectives)
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What it tests

  • Cognitive and clinical screening
  • Extended neuropsychological assessment
  • Blood biomarker sampling and APOE genotyping
  • Non-contrast brain CT scan
  • Multimodal neurophysiological assessment
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Where

3 sites
IRCCS Fondazione Don Gnocchi ETS
Florence, Italy
IRCCS Fondazione Don Carlo Gnocchi ETS, Santa Maria Nascente
Milan, Italy
Fondazione Don Carlo Gnocchi ETS, Istituto Palazzolo
Milan, Italy
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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