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A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight

RecruitingPhase 3Ages 18 Years - anyAllNovo Nordisk A/S
NCT07745504 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this clinical study is to look at how well a study medicine called cagrilintide helps people living with excess body weight to lose weight. Participants will either get cagrilintide, the active study medicine being tested or placebo, a medicine that has no active medicine in it. Which treatment participants get is decided by chance. Cagrilintide is a new medicine under development that doctors cannot prescribe yet, but it has been tested in humans before. Participants will be in this clinical study for about 9 months.

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📋 Eligibility rules (as published)
Inclusion criteria: * Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study. * Male or female (sex assigned at birth, inclusive of all gender identities). * Age 18 years or above at the time of signing the informed consent. * Body mass index (BMI) greater than or equal to (\>=) 30.0 kilograms per square meter (kg/m\^2), or BMI \>= 27.0 kg/m\^2 with the presence of at least one weight related comorbidity including, but not limited to, hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease. Exclusion criteria: * History of Type 1 Diabetes (T1D) or Type 2 Diabetes (T2D). * Previous dosing of marketed or non-marketed amylin-based compounds. * Treatment, or intention to initiate treatment, with any medication prescribed for the indication of weight management within 180 days before screening.
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What it tests

  • Cagrilintide
  • Placebo cagrilintide
  • Placebo semaglutide
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Where

36 sites
Hope Clin Res & Wellness
Conyers, United States
East West Med Res Inst
Honolulu, United States
Walgreens - Store 11760
Oak Park, United States
Midwest Inst For Clin Res
Indianapolis, United States
The Alliance for Multispecialty Research LLC AMR
Lexington, United States
PharmQuest
Greensboro, United States
KDCILM, LLC & Accellacare US, Inc.
Wilmington, United States
Coastal Carolina Res Ctr
North Charleston, United States

…and 28 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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