Bacillus Probiotic Spores in Supporting the Treatment of Chronic Inflammatory Bowel Disease

Inclusion Criteria: * Age 18 to 65 years. * Confirmed diagnosis of inflammatory bowel disease, including ulcerative colitis and Crohn's disease, according to the routine diagnostic procedures of Hanoi Medical University Hospital. * Receiving examination and treatment at Hanoi Medical University Hospital (including both inpatients and outpatients), with a minimum treatment or follow-up duration of 14 days * Willing and able to provide written informed consent. Exclusion Criteria: * Refusal to participate in the study. * Withdrawal from the study before completing 14 days of treatment. * Inability to comply with study procedures or inability to ensure adherence to the investigational product, as assessed by the investigator. * Moderate to severe hepatic or renal dysfunction, or other moderate to severe chronic cardiovascular, pulmonary, hepatic, or renal diseases that may affect general health status or require specialist treatment. * Presence of immune-related diseases. * Current use, or use within 4 weeks prior to screening, of biologic immunosuppressive therapies (for example, anti-TNF-α agents or vedolizumab).