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Prognostic Value of 2026 AHA/ACC Clinical Categorization in Acute Pulmonary Embolism Patients Presenting to the Emergency Department

Recruitingn/aAges 18 Years - anyAllMarmara University Pendik Training and Research Hโ€ฆ
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In plain words

What the trial is, and whether it could suit you

Background: The 2026 American Heart Association/American College of Cardiology (AHA/ACC) Pulmonary Embolism Guideline (Creager et al., Circulation 2026) introduced a novel five-category (A-E) clinical classification system with subcategories and an R modifier, replacing prior risk stratification frameworks. Prospective validation of this classification system using composite clinical outcomes is lacking. Objective: To evaluate the prognostic value of the 2026 AHA/ACC clinical categorization (Categories A-E plus R modifier) for predicting 30-day Major Adverse Pulmonary Embolism Events (MAPEE) in emergency department (ED) patients with acute pulmonary embolism (PE). Methods: Prospective observational cohort study conducted at Marmara University Faculty of Medicine Emergency Department, enrolling 600 consecutive adult patients with confirmed acute PE by computed tomography (CT) pulmonary an

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Age \>=18 years 2. Confirmed acute PE on CT pulmonary angiography (CTPA) within 24 hours of ED presentation 3. Informed consent obtained 4. Ability to complete 30-day follow-up Exclusion Criteria: 1. Chronic thromboembolic pulmonary hypertension (CTEPH) 2. Age \<18 years 3. Pregnancy 4. Incomplete CTPA or non-diagnostic imaging 5. Prior PE within 3 months 6. Refusal of informed consent 7. Inability to complete 30-day follow-up (no phone/address)
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What it tests

  • 2026 AHA/ACC Clinical Risk Categorization
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Where

1 site
Marmara University Pendik Training and Research Hospital
Istanbul, Turkey (Tรผrkiye)
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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