An Evaluation of Nutritional Status, Body Composition, and Dietary Intakes of Filipino Pediatric Patients With Inborn Errors of Intermediary Protein Metabolism

IEIPM PATIENTS Inclusion Criteria * Confirmed to have Amino Acid Disorders, Organic Acidurias, and Urea Cycle Defects by newborn screening or by biochemical testing in urine or plasma * Included in the metabolic registry of the Institute of Human Genetics-National Institutes of Health (IHG-NIH) and seen at the identified Newborn Screening Continuity Clinics (study sites) * With at least one (1) month of active medical treatment and/or with regular follow-up * The participant/parent/guardian or any legally acceptable representative consented to participate in the study Exclusion Criteria * With co-existing conditions not part of IEIPM and its complications (i.e. multiple congenital anomalies, hypoxic-ischemic encephalopathy, central brain abnormalities, any diagnosed systematic organic illness (e.g., renal, heart, or thyroid disease) or any suspected acute metabolic conditions other than IEIPM; * Currently enrolled in other research studies with intervention study design AGE- AND SEX-MATCHED HEALTHY CONTROLS Inclusion Criteria * Apparently healthy children, ages 0 month to 18 years and 364 days old at the time of the study recruitment; * Without any diagnosed genetic and/or metabolic disorders * With normal nutritional status (based on WHO CGS and Growth Reference 2007) * The participant/parent/guardian or any legally acceptable representative consented to participate in the study Exclusion Criteria * Diagnosed with any genetic and/or metabolic disorders * With any chronic illnesses known to affect growth and nutritional status * Currently enrolled in other research studies with intervention study design