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Comparing Cross-Linked and Non-Cross-Linked Hyaluronic Acid for Early Healing After Tooth Extraction

RecruitingNAAges 18 Years - 45 YearsAllCyprus Health and Social Sciences University
NCT07898163 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study compares early healing after a non-surgical tooth extraction in adults. Participants are assigned by chance to one of three groups: cross-linked hyaluronic acid placed in the extraction site using a gelatin sponge; non-cross-linked hyaluronic acid placed using a gelatin sponge; or a gelatin sponge alone. The study team measures the wound area using photographs at the time of extraction and on days 3, 7, and 14. A clinician who does not know the assigned group also assesses healing. Participants report their pain and use of pain-relief medicine. The study compares healing among the three groups.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-45 years * Systemically healthy * Light smokers, instructed to abstain completely from smoking for the first 72 postoperative hours * Requiring simple posterior tooth extraction * Clinically achievable hemostasis Exclusion Criteria: * Systemic diseases affecting healing * Pregnancy or lactation * Acute infection at the extraction site * Use of anti-inflammatory or immunosuppressive drugs * Surgical extraction requiring flap elevation or bone removal
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What it tests

  • Cross-linked sodium hyaluronate 1%
  • Non-cross-linked low-molecular-weight hyaluronic acid
  • Gelatin sponge
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Where

1 site
Cyprus Health and Social Sciences University
Mórfou, Cyprus
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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