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A Comparison of Pulsed Field Ablation (PFA) vs Cryoablation for Atrial Fibrillation Under Deep Sedation

RecruitingNAAges 18 Years - anyAllEast Sussex Healthcare NHS Trust
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In plain words

What the trial is, and whether it could suit you

Pulsed Field Ablation (PFA) has created a 'paradigm shift' within cardiac electrophysiology and the initial experience demonstrates that PFA is safe, rapid and effective compared to both radiofrequency ablation and cryoablation in atrial fibrillation (AF). Presently, AF ablation procedures in the UK using PFA are routinely performed using general anaesthetic (GA) support requiring an anaesthetist and ODP being present in all procedures. This need significantly limits the ability to use PFA technology to perform AF ablations, particularly in centres that have limited availability of GA provision. The need for GA also leads to extended patient recovery time post procedure which impacts patient throughput and has the potential to reduce hospital bed availability. The need for GA and the potential to limit patient throughput has negative implications for all hospitals in terms of cost. PFA

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patients with paroxysmal or persistent AF requiring a clinically-indicated AF ablation * Age \>18 years old * Able to give informed consent Exclusion Criteria: * Patients with a BMI \>35 * Any patient with a history of airway issues/Obstructive sleep apnoea/ obesity hypoventilation syndrome * Significant acid reflux or presence of a large hiatus hernia * Lack of capacity to give informed consent * Unable to lie flat for a minimum of 45 mins
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What it tests

  • Catheter ablation
  • Deep sedation with midazolam and fentanyl or midazolam and remifentanil
  • Sedation with midazolam and fentanyl
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Where

1 site
Eastbourne DGH
Eastbourne, United Kingdom
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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